Pure Large Cell Neuroendocrine Carcinoma of the Ovary with Metastasis to Cervix: A Rare Case Report and Review of Literature
Published: September 1, 2016 | DOI: https://doi.org/10.7860/JCDR/2016/21639.8554
Lakshmi Agarwal, Bhawna Gupta, Ayushi Jain
1. Assistant Professor, Department of Pathology, Govt Medical College, Kota, Rajasthan, India.
2. Senior Resident, Department of Pathology, Govt Medical College, Kota, Rajasthan, India.
3. Senior Resident, Department of Pathology, Govt Medical College, Kota, Rajasthan, India.
Correspondence
Dr. Lakshmi Agarwal,
Assistant Professor, Department of Pathology, Govt Medical College, Kota-324010, Rajasthan, India.
E-mail: drlaxmiagarwal@gmail.com
Ovarian Large Cell Neuroendocrine Carcinoma (LCNEC) is a recently described rare entity, which even more rarely occurs in a ‘pure’ form without any associated surface epithelial-stromal or germ cell component. Cervix metastasis of ovarian LCNEC has not been reported previously. We report here a case of ovarian LCNEC in a 35-year-old female who presented with abdominal pain and amenorrhea. Grossly the left ovary showed a solid cystic tumour measuring 6 cm in diameter. Histological examination showed a pure LCNEC without any associated component, confirmed by immunohistochemistry. Metastatic tumour deposits with numerous lymphovascular emboli were identified in the cervix. A comprehensive review of literature along with the various differential diagnosis is discussed.
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